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AdVerTiser index | Advertiser Index chewables AirSep, 47 Oxygen Generation systems 716-691-0202 • airsepcpd.com Merck Animal Health, 55 Activyl TickPlus (for dogs only) us.activyl.com Alpha Tech Pet, 30 Facility Maintenance 800-222-5537 • alphatechpet.com Merial, 5,7 Heartgard Plus heartgard.com ASPCA, 41 Poison Control 888-426-4435 • aspcapro.org/freebies Merial, 19 Frontline Tritak for Dogs (select states) • frontlinetritak.com AVMA, 10 Anniversary Celebration avma.org/150 Bayer Animal Health, 3 seresto BayerDVM.com Bayer Animal Health, 31 dermatology Products 800-633-3796 • BayerDVM.com Dan Scott & Associates, 17 Tono Pen Avia Vet 888-866-6736 • danscottandassociates.com Elanco, 48,49 Trifexis Parasite Protection 888-545-5973 • trifexis.com/vet Hill's Pet Nutrition, 9 Prescription Diet Metabolic Advanced Weight Solution hillsvet.com/metabolic Hill's Pet Nutrition, 11 Healthy Weight Diagnostic Tool hwp.hillsvet.com IDEXX Laboratories, 42 Snap 4Dx Plus Test idexx.com/snap4dxplus IDEXX Laboratories, 58 i-Vision digital imaging 855-627-6573 • idexx.com/1digital Konica Minolta, 63 ImagePilot Sigma and Informity 800-934-1034, ext. 1354 • medical.konicaminolta.us Frontline Plus for Dogs (select states) • frontline.com Merial, 39 Vaccines merialconnect.com Merial, Back Cover Tresaderm merialconnect.com CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian. INDICATIONS: For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense). DOSAGE: HEARTGARD® Plus (ivermectin/pyrantel) should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows: Dog Weight Chewables Per Month Ivermectin Content Pyrantel Content Color Coding 0n Foil Backing and Carton Up to 25 lb 26 to 50 lb 51 to 100 lb 1 1 1 68 mcg 136 mcg 272 mcg 57 mg 114 mg 227 mg Blue Green Brown HEARTGARD Plus is recommended for dogs 6 weeks of age and older. For dogs over 100 lb use the appropriate combination of these chewables. ADMINISTRATION: Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light. Because most dogs find HEARTGARD Plus palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended. HEARTGARD Plus should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog's last exposure to mosquitoes. Midmark, 76 Veterinary Dental Equipment 800-MIDMARK • midmarkanimalhealth.com When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of HEARTGARD Plus must be given within a month (30 days) of the last dose of the former medication. Novartis, 25 Parastar Plus DogsNeedAdventure.com Monthly treatment with HEARTGARD Plus also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites. Novartis, 32-34 Sentinel Flavor Tabs sentinelpet.com PNC Bank, Inside Back Cash Flow Insight 855-762-2361 • pnc.com/ cashflowinsight If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with HEARTGARD Plus and resumption of the recommended dosing regimen will minimize the opportunity for the development of adult heartworms. EFFICACY: HEARTGARD Plus Chewables, given orally using the recommended dose and regimen, are effective against the tissue larval stage of D.immitis for a month (30 days) after infection and, as a result, prevent the development of the adult stage. HEARTGARD Plus Chewables are also effective against canine ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). ACCEPTABILITY: In acceptability and field trials, HEARTGARD Plus was shown to be an acceptable oral dosage form that was consumed at first offering by the majority of dogs. PRECAUTIONS: All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus. While some microfilariae may be killed by the ivermectin in HEARTGARD Plus at the recommended dose level, HEARTGARD Plus is not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae. PRN Pharmacal, 78 ProZyme 800-874-9764 • prnpharmacal.com Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans. Putney, 57 Enrofloxacin 866-683-0660 • putneyvet.com/howtobuy ADVERSE REACTIONS: In clinical field trials with HEARTGARD Plus, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported following the use of HEARTGARD: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation. SCIL, 64 Diagnostic Equipment 877-724-5838 • scilvet.com Thundershirt, 70 Pet Anxiety solutions 866-892-2078 • ThunderShirt.com Merck Animal Health, Inside Front Nobivac Canine Flu H3N8 800-224-5318 Virbac, 66 AnxiTAne 800-338-3659 • virbacvet.com Merck Animal Health, 53 Activyl (for dogs and cats) us.activyl.com Virbac, 81 C.E.T. Brand Dental Chews 800-338-3659 • virbacvet.com Store between 68°F - 77°F (20°C - 25°C). Excursions between 59°F - 86°F (15°C - 30°C) are permitted. Protect product from light. SAFETY: HEARTGARD Plus has been shown to be bioequivalent to HEARTGARD, with respect to the bioavailability of ivermectin. The dose regimens of HEARTGARD Plus and HEARTGARD are the same with regard to ivermectin (6 mcg/kg). Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. HEARTGARD demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials and bioequivalency studies, support the safety of HEARTGARD products in dogs, including Collies, when used as recommended. HEARTGARD Plus has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with HEARTGARD Plus in a heartworm disease prevention program. In one trial, where some pups had parvovirus, there was a marginal reduction in efficacy against intestinal nematodes, possibly due to a change in intestinal transit time. HOW SUPPLIED: HEARTGARD Plus is available in three dosage strengths (See DOSAGE section) for dogs of different weights. Each strength comes in convenient cartons of 6 and 12 chewables. For customer service, please contact Merial at 1-888-637-4251. ®HEARTGARD and the Dog & Hand logo are registered trademarks of Merial. ©2013 Merial Limited, Duluth, GA. All rights reserved. HGD13TRTRADEAD3 (03/13). May/June 2013 Today's Veterinary Practice 7