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| ACVN NutritioN Notes 84 today's Veterinary Practice May/June 2014 tvpjournal.com table 7. anecdotal & experimental doses: Common veterinary nutraceuticals CATEGORY SUPPLEMENT DOSE PER DAY* Antioxidants Vitamin C (ascorbic acid) 50 mg/kg Vitamin E (alpha-tocopherol) 10–20 iu/kg Alpha lipoic acid 11 mg/kg (dogs only) Polyunsaturated Fatty Acids Eicosapentaenoic + docosahexaneoic acids 1–3 mg/calorie Amino Acids L-carnitine 50–200 mg/kg S-adenosylmethionine 15–20 mg/kg Taurine 50 mg/kg Glutamine 50-200 mg/kg Lysine 400 mg/cat L-theanine 3–5 mg/kg Q 12 H Joint Supplements Glucosamine ≥ 25 mg/kg Chondroitin ≥ 15–20 mg/kg MSM > 10 mg/kg Green-lipped mussel 30 mg/kg Herbal Supplements Artemisinin > 4 mg/kg Curcumin 5–50 mg/kg Silybin or Milk thistle extract 1–2 mg/kg (silybin) or 5–10 mg/kg (extract) Yunnan Baiyao 12.5–25 mg/kg Q 6–8 H as needed Yun Zhi (C versicolor extract) 100 mg/kg *Except where noted otherwise Weight management that works in the real world. 1 Data on fle. Hill's Pet Nutrition, Inc. ©2014 Hill's Pet Nutrition, Inc. ®/™ Trademarks owned by Hill's Pet Nutrition, Inc. [ canned + d r y + t r e at s ] Available in canine and feline formulas ExpEct SomEthing Different now with our most advanced antioxidant formula ever! 12. ernst e. adulteration of Chinese herbal medicines with synthetic drugs: a systematic review. J Intern Med 2002; 252:107-113. 13. Shmalberg J, Hill rC, Scott KC. nutrient and metal analyses of Chinese herbal products marketed for veterinary use. J Anim Physiol Anim Nutr (Berl) 2013; 97:305-314. 14. national research Council ad Hoc Committee on dog and Cat nutrition. Nutrient Requirements of Dogs and Cats. washington dC: national academies Press, 2006. 15. dennert g, Zwahlen m, brinkman m, et al. Selenium for preventing cancer. Cochrane Database Syst Rev 2011; Cd005195. 16. gupta yK, Sharma SS. antiemetic activity of antioxidants against cisplatin-induced emesis in dogs. Environ Toxicol Pharmacol 1996; 1:179-184. 17. Shmalberg J. nutritional secondary hyperparathyroidism and taurine deficiency in a dog fed a home-prepared diet during Chinese food therapy. Am J Trad Chinese Vet Med 2013; 8:69-72. 18. wakshlag JJ, rassnick Km, malone eK, et al. Cross-sectional study to investigate the association between vitamin d status and cutaneous mast cell tumours in labrador retrievers. Br J Nutr 2011; 106:S60-S63. 19. rhouma m, de Oliveira el warrak a, troncy e, et al. anti-inflammatory response of dietary vitamin e and its effects on pain and joint structures during early stages of surgically induced osteoarthritis in dogs. Can J Vet Res 2013; 77:191-198. 20. vandeweerd Jm, Cambier C, gustin P. nutraceuticals for canine liver disease: assessing the evidence. Vet Clin North Am Small Anim Pract 2013; 43:1171-1179. 21. bauer Je. therapeutic use of fish oils in companion animals. JAVMA 2011; 239:1441- 1451. 22. Fritsch da, allen ta, dodd Ce, et al. a multicenter study of the effect of dietary supplementation with fish oil omega-3 fatty acids on carprofen dosage in dogs with osteoarthritis. JAVMA 2010; 236:535-539. 23. Zicker SC, Jewell de, yamka rm, et al. evaluation of cognitive learning, memory, psychomotor, immunologic, and retinal functions in healthy puppies fed foods fortified with docosahexaenoic acid-rich fish oil from 8 to 52 weeks of age. JAVMA 2012; 241:583-594. 24. denapoli JS, dodman nH, Shuster l, et al. effect of dietary protein content and tryptophan supplementation on dominance aggression, territorial aggression, and hyperactivity in dogs. JAVMA 2000; 217:504-508. 25. gwaltney-brant Sm, albretsen JC, Khan Sa. 5-Hydroxytryptophan toxicosis in dogs: 21 cases (1989-1999). JAVMA 2000; 216:1937-1940. 26. Kawaguchi t, taniguchi e, Sata m. effects of oral branched-chain amino acids on hepatic encephalopathy and outcome in patients with liver cirrhosis. Nutr Clin Pract 2013; 28:580-588. 27. wernerman J. Clinical use of glutamine supplementation. J Nutr 2008; 138:2040S-2044S. 28. ibrahim wH, bailey n, Sunvold gd, et al. effects of carnitine and taurine on fatty acid metabolism and lipid accumulation in the liver of cats during weight gain and weight loss. Am J Vet Res 2003; 64:1265-1277. 29. araujo Ja, de rivera C, ethier Jl, et al. anXitane (r) tablets reduce fear of human beings in a laboratory model of anxiety-related behavior. J Vet Behav Clin App Res 2010; 5:268-275. (References continued on page 96) 2014-0506_NutritionNotes_Nutraceuticals_RECONFIGURED_FOR ADS.indd 84 5/24/2014 8:17:12 PM