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Today's Veterinary Practice July/August 2014 14 tvpjournal.com Today's VeTerinary news ReCALL Hospira Announces Nationwide Recall of IV Fluids Hospira, Inc is initiating a voluntary nationwide user-level recall of one lot of Lac- tated Ringers and 5% Dextrose Injection, USP, 1000 mL, Flexible Container, NDC 0409-7929-09, Lot 35-118-JT, Expiry 1NOV2015. This recall is being conducted as a precautionary measure and is due to one con- firmed customer report where particulate was iden- tified within the solution of the primary container, indicative of mold. Analysis of the primary container indicated a puncture, causing the primary container to leak. As of July 10, 2014, Hospira has not received reports of any other adverse events associated with this lot, nor has identified any quality issues with re- tention samples. However, anyone with an existing inventory should stop use and distribution, quarantine the product immediately, and call Stericycle at 1-888- 912-8457 to arrange for the return of the product. For clinical inquiries, please contact Hospira at 1-800-441-4100 or medcom@hospira.com. To report ad- verse events or side effects related to the use of this product to the FDA, visit fda .gov/medwatch/report.htm. Survey Raises Concerns about Tick Control Merial, the maker of FRONTLINE Plus, has announced the results of a pet owner survey showing that 63% of people who purchased flea control products or flea control/heartworm preventive products believed the products would kill ticks, when in fact they were not effective against ticks. W hile pet owners appear to understand the need to use products that kill ticks, many are misinformed about the products they are currently using. In fact, 30% of people who say they would only purchase a product that kills ticks had purchased products that are not effective against ticks. "Fleas and ticks are two very different parasites," said Dr. Michael Murray, DVM, Merial, adding that the FRONTLINE Plus brand is effective in killing both parasites. For more information on the survey, visit frontline.com. Please send any news, press releases, or information relevant to veterinary professionals to KSoldavin@todaysveterinarypractice.com for publication consideration in Today's Veterinary News. VetGirl Offers RACE-Approved CE Webinars VetGirl—a multimedia service that prov ides veter ina r y continuing education through podcasts, webinars, videos, and blogs—regularly hosts R ACE-approved continuing education webinars. Upcoming webinars include August 20: Communicating Value for Preventive Dentistry, presented by Wendy S. Myers from 7 pm to 8 pm EST (6 pm – 7 pm CST) and August 27: Hot Weather Advisory! Management of Heat Stroke in Dogs, presented by Marie Holowaychuk, DVM, Diplomate ACVECC, from 7 pm to 9 pm EST (6 pm – 8 pm CST). Total R ACE- approved CE credit hours are 1 hour and 2 hours, respectively. Webinars are available at vetgirlontherun .com/webinars; to register for a free 30-day trial subscription, visit vetgirlontherun.com/trial-member- webinar-review. (selamectin) ® Topical Parasiticide For Dogs and Cats BRIEF SUMMARY: See package insert for full prescribing information. CAUTION: US Federal law restricts this drug to use by or on the order of a licensed veterinarian. INDICATIONS: Revolution is recommended for use in dogs six weeks of age or older and cats eight weeks of age and older for the following parasites and indications: Dogs: Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Cteno cephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Revolution also is indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Derma centor variabilis. Cats: Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the preven tion and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Diro filaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Revolution is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats. WARNINGS: Not for human use. Keep out of the reach of children. In humans, Revolution may be irritating to skin and eyes. Reactions such as hives, itching and skin redness have been reported in humans in rare instances. Individuals with known hypersensitivity to Revolution should use the product with caution or consult a health care professional. Revolution contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with eyes occurs, then flush eyes copiously with water. In case of ingestion by a human, contact a physician immediately. The material safety data sheet (MSDS) provides more detailed occupational safety information. For a copy of the MSDS or to report adverse reactions attributable to exposure to this product, call 1-888-963-8471. Flammable - Keep away from heat, sparks, open flames or other sources of ignition. Do not use in sick, debilitated or underweight animals (see SAFETY). PRECAUTIONS: Prior to administration of Revolution, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Revolution is not effective against adult D. immitis and, while the number of circulating microfilariae may decrease following treatment, Revolution is not effective for micro- filariae clearance. Hypersensitivity reactions have not been observed in dogs with patent heartworm infections administered three times the recommended dose of Revolution. Higher doses were not tested. ADVERSE REACTIONS: Pre-approval clinical trials: Following treatment with Revolution, transient localized alopecia with or without inflammation at or near the site of application was observed in approximately 1% of 691 treated cats. Other signs observed rarely (≤0.5% of 1743 treated cats and dogs) included vomiting, loose stool or diarrhea with or without blood, anorexia, lethargy, salivation, tachypnea, and muscle tremors. Post-approval experience: In addition to the aforementioned clinical signs that were reported in pre-approval clinical trials, there have been reports of pruritus, urticaria, erythema, ataxia, fever, and rare reports of death. There have also been rare reports of seizures in dogs (see WARNINGS). SAFETY: Revolution has been tested safe in over 100 different pure and mixed breeds of healthy dogs and over 15 different pure and mixed breeds of healthy cats, including pregnant and lactating females, breeding males and females, puppies six weeks of age and older, kittens eight weeks of age and older, and avermectin-sensitive collies. A kitten, estimated to be 5–6 weeks old (0.3 kg), died 8 1 ⁄ 2 hours after receiving a single treatment of Revolution at the recommended dosage. The kitten displayed clinical signs which included muscle spasms, salivation and neurological signs. The kitten was a stray with an unknown history and was malnourished and underweight (see WARNINGS). DOGS: In safety studies, Revolution was administered at 1, 3, 5, and 10 times the recommended dose to six-week-old puppies, and no adverse reactions were observed. The safety of Revolution administered orally also was tested in case of accidental oral ingestion. Oral administration of Revolution at the recommended topical dose in 5- to 8-month-old beagles did not cause any adverse reactions. In a pre-clinical study selamectin was dosed orally to ivermectin-sensitive collies. Oral administration of 2.5, 10, and 15 mg/kg in this dose escalating study did not cause any adverse reactions; how- ever, eight hours after receiving 5 mg/kg orally, one avermectin-sensitive collie became ataxic for several hours, but did not show any other adverse reactions after receiving subsequent doses of 10 and 15 mg/kg orally. In a topical safety study conducted with avermectin-sensitive collies at 1, 3 and 5 times the recommended dose of Revolution, salivation was observed in all treatment groups, including the vehicle control. Revolution also was administered at 3 times the recommended dose to heartworm infected dogs, and no adverse effects were observed. CATS: In safety studies, Revolution was applied at 1, 3, 5, and 10 times the recommended dose to six-week-old kittens. No adverse reactions were observed. The safety of Revolution administered orally also was tested in case of accidental oral ingestion. Oral administration of the recommended topical dose of Revolution to cats caused salivation and intermittent vomiting. Revolution also was applied at 4 times the recommended dose to patent heartworm infected cats, and no adverse reactions were observed. In well-controlled clinical studies, Revolution was used safely in animals receiving other frequently used veterinary products such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips. STORAGE CONDITIONS: Store below 30°C (86°F). HOW SUPPLIED: Available in eight separate dose strengths for dogs and cats of different weights (see DOSAGE). Revolution for puppies and kittens is available in cartons containing 3 single dose tubes. Revolution for cats and dogs is available in cartons containing 3 or 6 single dose tubes. NADA 141-152, Approved by FDA Distributed by: Zoetis Inc. Kalamazoo, MI 49007 www.revolutionpet.com 10309504