Today's Veterinary Practice

JUL-AUG 2014

Today's Veterinary Practice provides comprehensive information to keep every small animal practitioner up to date on companion animal medicine and surgery as well as practice building and management.

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New study shows no dogs pretreated with CERENIA ® (maropitant citrate) demonstrated pre-surgical acute emesis resulting from opioid use. 1 In a new study evaluating the effectiveness of CERENIA in the prevention of acute emesis associated with the admin- istration of morphine, none of the CERENIA-treated dogs vomited after receiving the opioid, while 93.8 percent of the placebo-treated dogs vomited—with 6O percent vomiting more than once. *,1 The blinded, placebo-controlled study was conducted to evaluate the effi cacy of CERENIA to prevent vomiting when dogs were dosed 45 minutes prior to the preoperative administration of morphine. Dogs then underwent a routine spay or castration. There was signifi cantly * less vomiting in the CERENIA-treated dogs (n=15) than in the placebo-treated dogs (n=16). "The incidence of vomiting can depend on the specifi c opioid and the dose and route it is given," said Bonnie L. Hay Kraus, DVM, Diplomate ACVAA, ACVS, anesthesiologist and assistant professor, Veterinary Clinical Sciences, at Iowa State University. Dr. Hay Kraus's own research supports the prevention of acute emesis demonstrated in the study. "Typically 5O to 75 percent of patients will vomit after preoperative opioid administration. 2 The benefit of CERENIA is that it is safe and controls vomiting effectively." New study reveals CERENIA-treated dogs returned to normal feeding † sooner and consumed more food. *,1 Along with prevention of vomiting, the new research indicated a signifi cantly * higher number of dogs treated with CERENIA preoperatively returned to normal feeding † by 2O hours (9O.9 percent) versus the placebo-treated dogs (41.7 percent). An additional observed fi nding showed CERENIA-treated dogs consumed 4.85x as much food compared to the placebo-treated dogs, with the CERENIA-treated dogs having a mean total food consumption of 19O.O grams and the placebo-treated dogs 39.1 grams. 1 "Returning to feeding more quickly is a huge benefi t in post- operative patients," Dr. Hay Kraus agreed. "The surgical and anesthetic procedures put patients in a negative energy balance that is not conducive to healing. Earlier return to feeding helps reestablish normal GI motility and can reverse that negative energy balance, ultimately helping patients to recover. What I do in my patients, and what I teach my students, is to pretreat patients with CERENIA before administration of the anesthetic premedication of opioids—and we have seen good results." This evidence suggests veterinarians consider the administration of CERENIA as part of their preoperative protocols when using opioids. IMPORTANT SAFETY INFORMATION: Use CERENIA Injectable for acute vomiting in dogs 8 weeks and older. Safe use has not been evaluated in cats and dogs with gastrointestinal obstruction, or those that have ingested toxins. Use with caution in dogs with hepatic dysfunction. Pain and vocalization upon injection is a common side effect. In people, topical exposure may elicit localized allergic skin reactions, and repeated or prolonged exposure may lead to skin sensitization. See Brief Summary of full Prescribing Information on page XX. All trademarks are the property of Zoetis Inc., its af liates and/or its licensors. ©2O14 Zoetis Inc. All rights reserved. August 2O14. CER-OOO34B Data on fi le, Zoetis Study Report 1961R-6O-11-A81. 2014 Zoetis Inc. Hay Kraus BL. Ef cacy of maropitant in preventing vomiting in dogs premedicated with hydromorphone. Vet Anaesth Analg . Epub 2O12 Oct 2O. Statistically signifi cant at p

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