Today's Veterinary Practice provides comprehensive information to keep every small animal practitioner up to date on companion animal medicine and surgery as well as practice building and management.
Issue link: http://todaysveterinarypractice.epubxp.com/i/354788
New study shows no dogs pretreated with CERENIA
demonstrated pre-surgical acute emesis resulting from opioid use.
In a new study evaluating the effectiveness of CERENIA in
the prevention of acute emesis associated with the admin-
istration of morphine, none of the CERENIA-treated dogs
vomited after receiving the opioid, while 93.8 percent of the
placebo-treated dogs vomited—with 6O percent vomiting
more than once.
The blinded, placebo-controlled study was conducted to
evaluate the effi cacy of CERENIA to prevent vomiting when
dogs were dosed 45 minutes prior to the preoperative
administration of morphine. Dogs then underwent a routine
spay or castration. There was signifi cantly
less vomiting in
the CERENIA-treated dogs (n=15) than in the placebo-treated
"The incidence of vomiting can depend on the specifi c opioid
and the dose and route it is given," said Bonnie L. Hay Kraus,
DVM, Diplomate ACVAA, ACVS, anesthesiologist and assistant
professor, Veterinary Clinical Sciences, at Iowa State University.
Dr. Hay Kraus's own research supports the prevention of acute
emesis demonstrated in the study. "Typically 5O to 75
percent of patients will vomit after preoperative opioid
The benefit of CERENIA is that it is safe
and controls vomiting effectively."
New study reveals CERENIA-treated dogs returned
to normal feeding
sooner and consumed more food.
Along with prevention of vomiting, the new research indicated
a signifi cantly
higher number of dogs treated with CERENIA
preoperatively returned to normal feeding
by 2O hours (9O.9
percent) versus the placebo-treated dogs (41.7 percent).
An additional observed fi nding showed CERENIA-treated
dogs consumed 4.85x as much food compared to the
placebo-treated dogs, with the CERENIA-treated dogs
having a mean total food consumption of 19O.O grams
and the placebo-treated dogs 39.1 grams.
"Returning to feeding more quickly is a huge benefi t in post-
operative patients," Dr. Hay Kraus agreed. "The surgical and
anesthetic procedures put patients in a negative energy
balance that is not conducive to healing. Earlier return to
feeding helps reestablish normal GI motility and can reverse
that negative energy balance, ultimately helping patients to
recover. What I do in my patients, and what I teach my students,
is to pretreat patients with CERENIA before administration of
the anesthetic premedication of opioids—and we have seen
good results." This evidence suggests veterinarians consider
the administration of CERENIA as part of their preoperative
protocols when using opioids.
IMPORTANT SAFETY INFORMATION: Use CERENIA Injectable for acute vomiting in dogs 8 weeks and older. Safe use has not been evaluated
in cats and dogs with gastrointestinal obstruction, or those that have ingested toxins. Use with caution in dogs with hepatic dysfunction.
Pain and vocalization upon injection is a common side effect. In people, topical exposure may elicit localized allergic skin reactions, and
repeated or prolonged exposure may lead to skin sensitization. See Brief Summary of full Prescribing Information on page XX.
All trademarks are the property of Zoetis Inc., its af liates and/or its licensors. ©2O14 Zoetis Inc. All rights reserved. August 2O14. CER-OOO34B
Data on fi le, Zoetis Study Report 1961R-6O-11-A81. 2014 Zoetis Inc.
Hay Kraus BL. Ef cacy of maropitant in preventing vomiting in dogs premedicated with hydromorphone.
Vet Anaesth Analg . Epub 2O12 Oct 2O.
Statistically signifi cant at p