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tvpjournal.com | January/February 2016 | Today's VeTerinary PracTice elemenTs oF oncology Peer reviewed 57 reduced osteolysis, and decreased tumor size. 32 see Consider This Case: Palliative Radiation for Squamous Cell Carcinoma (page 58) for a case presentation that demonstrates the use of palliative radiation. Tumors with a favorable long-term prognosis and postoperative microscopic local disease, such as an incompletely resected low- to intermediate- grade soft tissue sarcoma of the distal limb, should never be treated with palliative protocols. owners who cannot afford defnitive therapy should be counseled regarding the probability of recurrence (relatively low) and advised to consider palliative radiation therapy or amputation at a later date should the tumor recur. The probability of a late side effect in slowly proliferating normal tissues, such as the central nervous system, smooth muscle, or bone, increases exponentially when palliative treatment protocols with large fraction sizes, such as those used in palliative radiation therapy, are employed. 6 Differences in Therapy & Side Effects While defnitive treatments are delivered on a daily basis in 16 to 24 treatment sessions, palliative radiation therapy is delivered in 1 to 5 treatment sessions, either daily or once weekly. The fraction is also typically larger in palliative protocols, although the total dose delivered is smaller; defnitive treatment fractions range from 2 to 3 gy (total prescribed dose, 48–60 gy), while palliative treatment fractions range from 4 to 8 gy (total prescribed dose, 20–32 gy). Higher total doses delivered over a longer period of time are more likely to result in acute side effects in the treated areas, such as mucositis, dry desquamation, and moist desquamation. lower total doses delivered over a short period of time are less likely to result in acute side effects, while still delivering a high enough dose to have an effect on the tumor, including pain relief, reduced tumor size, and decreased mechanical stretching due to space-occupying masses. new techniques, such as imrT, can be used to help minimize the potential for acute side effects in sensitive areas, such as the eye (see Nasal Tumors: Advanced Techniques Lead to Fewer Side Effects). West: 800.745.4725 | East: 800.872.1001 Test Express: 888.397.8378 www.antechdiagnostics.com ANTECH®'s Pre-Op Diagnostics ANTECH Diagnostics provides you the peace-of-mind you need when your patients require anesthesia, surgerical procedures and general dentistry. At ANTECH, it is not just a blood test, it is our patient too! For more, visit us at NAVC Booth #1639 and WVC Booth #3916.