Today's Veterinary Practice

SEP-OCT 2016

Today's Veterinary Practice provides comprehensive information to keep every small animal practitioner up to date on companion animal medicine and surgery as well as practice building and management.

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IMPORTANT SAFETY INFORMATION: Use CERENIA Injectable for vomiting in cats 4 months and older. Use subcutaneously for acute vomiting in dogs 2 to 4 months of age or either subcutaneously or intravenously in dogs 4 months of age and older. Safe use has not been evaluated in cats and dogs with gastrointestinal obstruction, or those that have ingested toxins. Use with caution in cats and dogs with hepatic dysfunction. Pain and vocalization upon injection is a common side effect. In people, topical exposure may elicit localized allergic skin reactions, and repeated or prolonged exposure may lead to skin sensitization. See Brief Summary of full Prescribing Information on page XX. All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. ©2016 Zoetis Services LLC. All rights reserved. CER-00215 *Dr. Grubb is a former colleague of, consultant to and speaker for Zoetis. 1 Hay Kraus BL. Efficacy of maropitant in preventing vomiting in dogs premedicated with hydromorphone. Vet Anaesth Analg. 2013;40(1):28-34. doi:10.1111/j.1467-2995.2012.00788.x. 2 Ramsey D, Fleck T, Berg T, et al. Cerenia prevents perioperative nausea and vomiting and improves recovery in dogs undergoing routine surgery. Intern J Appl Res Vet Med. 2014;12(3):228-237. http://www.jarvm.com/articles/Vol12Iss3/Vol12%20Iss3McCall.pdf. 3 Data on file, Study Report No. A461N-US-13-289, 2015 Zoetis Inc. 4 Data on file, Study Report No. A461N-US-13-080, 2015 Zoetis Inc. 5 Data on file, Study Report No. A366N-US-13-276, 2015 Zoetis Inc. 6 Data on file, Study Report No. A386N-US-13-077, 2015 Zoetis Inc. In a blinded, placebo-controlled study, CERENIA was used preoperatively to prevent vomiting. Dosing occurred 45 minutes prior to the preoperative administration of morphine, and results demonstrated a significant (p<0.05) difference in the incidence of vomiting. 2 Dr. Grubb views the return to normal canine feeding as a critical indicator for the well- being of the patient. "It is an important part of normal healing as well as something we can measure. It's not just about anesthesia, it's about overall patient care," she explained. "The improved flexibility can lead to better patient outcomes due to increased uptake and increased maropitant utilization. We're adding to patient care by decreasing vomiting and then speeding up the return to normal feeding. When a dog comes home, doesn't want to eat and possibly vomits, it does not look like a successful procedure [to a dog owner]." The approved intravenous use of CERENIA in cats and dogs 4 months and older was obtained in January 2016 and is now reflected on the label. In two separate bioequivalence studies conducted in 2015 by Zoetis in dogs and cats, when delivered intravenously, CERENIA reached concentration and absorption levels as quickly as with subcutaneous injection. 3,4 Additionally, two separate safety studies in dogs and cats indicated no related effects on survival or clinical findings, and there were no reports of pain on intravenous injection. 5,6 "We now have the flexibility to treat whenever we need to treat the patient," said Dr. Grubb. "If we already have an IV catheter in the dog, why stick it with another needle?" To learn more about making CERENIA a part of a preoperative protocol when using opioids, visit cereniadvm.com. 36.

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