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MRs infecTions | IN SUMMARY Methicillin- and multidrug-resistant staphylococcal infections are becoming increasingly common in veterinary patients. • Empiric antimicrobial selection is difficult and treatment failure is common. • Culture and susceptibility testing is indicated for management of staphylococcal infections, particularly canine pyoderma and surgical site infections. • Topical antimicrobial therapy may be useful for infection treatment and prevention in cases of limited systemic antimicrobial options or adverse drug effects. • Strict hygiene practices should b e o b s er v e d to l i m it b a c t er i a l transmission.n cons = coagulase-negative staphylococci; MRsa = methicillin-resistant Staphylococcus aureus; MRsP = methicillin-resistant Staphylococcus pseudintermedius; MRss = methicillin-resistant Staphylococcus schleiferi; MssP = methicillin-susceptible Staphylococcus pseudintermedius References next page. Christine L. Cain, DVM, Diplomate ACVD, is assistant professor of dermatology and allergy at the University of Pennsylvania School of Veterinary Medicine. Dr. Cain's clinical interests include management of allergic, immune-mediated, and infectious skin diseases. Her research is primarily focused on infectious disease and antimicrobial resistance, particularly staphylococcal antimicrobial resistance. Dr. Cain received her DVM from Ohio State University and completed an internship in small animal medicine and surgery at Red Bank Veterinary Hospital in Tinton Falls, New Jersey, followed by a residency in dermatology at University of Pennsylvania. May/June 2013 Today's Veterinary Practice 31