Today's Veterinary Practice provides comprehensive information to keep every small animal practitioner up to date on companion animal medicine and surgery as well as practice building and management.
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September/October 2016 | tvpjournal.com cO n S ider Thi S c a S e Peer r eviewed 100 References 1. d iBartola SP. Metabolic acid-base disorders. i n d iBartola SP (ed): Fluid, Electrolyte, and Acid-Base Disorders, 3rd ed. St. Louis: e lsevier, 2006, pp 251-283. 2. Peterson M e , Kintzer PP, Kass P h . Pretreatment clinical and laboratory findings in dogs with hypoadrenocorticism: 225 cases (1979-1993). JAVMA 1996; 208:85-91. 3. d iBartola SP, Johnson S e , d avenport d J, et al. c linicopathologic findings resembling hypoadrenocorticism in dogs with primary gastrointestinal disease. JAVMA 1985; 187:60-63. 4. r uckstuhl n , h oerauf a , Tomsa K, et al. Pseudohypoadrenocorticism in two Siberian huskies with gastrointestinal parasitoses. Schweiz Arch Tierheilkd 2002; 144:75-81. 5. Graves TK, Schall W d , r efsal K, et al. Basal and ac T h -stimulated plasma aldosterone concentration are normal or increased in dogs with trichuriasis- associated pseudohypoadrenocorticism. J Vet Intern Med 1994;8:287-289. 6. Willard M d , Fossum TW, Torrance a , et al. h yponatremia and hyperkalemia associated with idiopathic or experimentally induced chylothorax in four dogs. JAVMA 1991; 199:353-358. 7. d iBartola SP. d isorders of potassium. i n d iBartola SP (ed): Fluid Therapy in Small Animal Practice, 2nd ed. Philadelphia: WB Saunders, 2000, pp 83-107. 8. Kintzer PP, Peterson M e . Primary and secondary canine hypoadrenocorticism. Vet Clin North Am Small Anim Prac 1997; 27:349-357. 9. Kintzer PP, Peterson M e . Treatment and long-term follow-up of 205 dogs with hypoadrenocorticism. J Vet Intern Med 1997; 11:43-49. 10. Plumb dc . Plumb's Veterinary Drug Handbook, 7th ed. Stockholm: Wiley- Blackwell, 2011. 11. Lifton SJ, King LG, Zerbe ca . Glucocorticoid deficient hypoadrenocorticism in dogs: 18 cases (1986-1995). JAVMA 1996; 209:2076-2081. 12. Peterson M e , Kintzer PP, Kass P h . Pretreatment clinical and laboratory findings in dogs with hypoadrenocorticism: 225 cases (1979-1993). JAVMA 1996; 208:85-91. 13. Schaer M, c hen c L. a clinical survey of 48 dogs with adrenocortical hypofunction. JAAHA 1983; 19:443-452. 14. Shaker e , h urvitz a , Peterson M. h ypoadrenocorticism in a family of standard poodles. JAVMA 1988; 192:1091-1092. 15. Famula T r , Belanger JM, Oberbauer a M. h eritability and complex segregation analysis of hypoadrenocorticism in the standard poodle. J Sm Anim Prac 2003; 442:2. 16. Oberbauer a M, Benemann KS, Belanger JM, et al. i nheritance of hypoadrenocorticism in bearded collies. Am J Vet Res 2002; 63:643-647. 17. Smallwood LJ, Barsanti J a . h ypoadrenocorticism in a family of Leonbergers. JAAHA 1995; 31:301-305. 18. Burton S, d elay J, h olmes a , et al. h ypoadrenocorticism in young related n ova Scotia duck tolling retrievers. Can Vet J 1997; 38:231-234. J U stin E a . lEE Justine A. Lee, DVM, Diplomate ACVECC & ABT, is the CEO and founder of VETgirl (vetgirlontherun.com), a subscription-based podcast and webinar service that offers RACE-approved online veterinary continuing education. She recently received the NAVC Speaker of the Year Award (2011, 2015, 2016) and is the author and editor of several veter - inary textbooks, book chapters, and scientific publications. She completed her veterinary training at Cornell University, Angell Animal Medical Center (Boston), and University of Pennsylvania. g arr E t Pac H ting E r Garret Pachtinger, VMD, Diplomate ACVECC, is the COO and co-founder of VETgirl (vetgir - lontherun.com). He is also a criticalist at the Veterinary Specialty & Referral Center in Lev - ittown, Pennsylvania. He completed his veteri- nary training at University of Pennsylvania. ZYCORTAL ® Suspension (desoxycorticosterone pivalate injectable suspension) Mineralocorticoid for subcutaneous use in dogs only. Brief Summary (For Full Prescribing Information, see package insert) CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: Desoxycorticosterone pivalate is a mineralocorticoid hormone. Zycortal Suspension contains 25mg/ml of desoxycorticosterone pivalate. INDICATION: For use as replacement therapy for mineralocorticoid deficiency in dogs with primary hypoadrenocorticism (Addison's disease). CONTRAINDICATIONS: Do not use ZYCORTAL Suspension in dogs that have previously had a hypersensitivity reaction to desoxycorticosterone pivalate. WARNINGS: Use ZYCORTAL Suspension with caution in dogs with congestive heart disease, edema, severe renal disease or primary hepatic failure. Desoxycorticosterone pivalate may cause polyuria, polydipsia, increased blood volume, edema and cardiac enlargement. Excessive weight gain may indicate fluid retention secondary to sodium retention. HUMAN WARNINGS: Not for human use. Keep this and all drugs out of the reach of children. Consult a physician in case of accidental human exposure. PRECAUTIONS: Any dog presenting with severe hypovolemia, dehydration, pre-renal azotemia and inadequate tissue perfusion ("Addisonian crisis") must be rehydrated with intravenous fluid (saline) therapy before starting treatment with ZYCORTAL Suspension. The effectiveness of ZYCORTAL Suspension may be reduced if potassium-sparing diuretics, such as spironolactone, are administered concurrently. ADVERSE REACTIONS: The field safety analysis included evaluation of 152 dogs. The most common adverse reactions reported are polyuria, polydipsia, depression/lethargy, inappropriate urination, alopecia, decreased appetite/anorexia, panting, vomiting, diarrhea, shaking/trembling, polyphagia, urinary tract infection, urinary tract incontinence and restlessness. Reports of anaphylaxis and anemia have been associated with a different desoxycorticosterone pivalate injectable suspension product. Distributed by: Dechra Veterinary Products 7015 College Boulevard, Suite 525 Overland Park, KS 66211 ZYCORTAL is a trademark of Dechra Ltd © 2015, All rights reserved NADA 141-444, Approved by FDA Z Y C O R T A L ® SUSPENSION (desoxycorticoster one p i v a l a t e i n j e c t a b l e s u s p e n s i o n )