Today's Veterinary Practice

MAY-JUN 2017

Today's Veterinary Practice provides comprehensive information to keep every small animal practitioner up to date on companion animal medicine and surgery as well as practice building and management.

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PEER REVIEWED References 1. Overall KL, Dunham AE, Frank D. Frequency of nonspecific clinical signs in dogs with separation anxiety, storm/thunderstorm phobia, and noise phobia, alone or in combination. JAVMA 2001;219(4):467-473. 2. Tiira K, Lohi H. Early life experiences and exercise associate with canine anxieties. PLoS One 2015;10(11):e0141907. 3. Tiira K, Sulkama S, Lohi, H. Prevalence, cormorbidity, and behavioral variation in canine anxiety. J Vet Behav Clin Appl Res 2016;16:36-44. 4. Hammerle M, Horst C, Levine E, et al. AAHA 2015 Canine and Feline Behavior Management Guidelines. aaha.org/professional/resources/behavior_management_ guidelines.aspx. Accessed November 2016. 5. Overall KL. Manual of Clinical Behavioral Medicine for Dogs and Cats. St, Louis, MO: Elsevier; 2013. 6. Overall KL, Tiira K, Broach D, Bryant D. Genetics and behavior: a guide for practitioners. Vet Clin North Am Small Anim Pract 2014;44(3):483-505. 7. Davis M. Neurobiology of fear responses: the role of the amygdala. J Neuropsychiatry Clin 1997;9(3):382-402. 8. Cusack B, Nelson A, Richelson E. Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl) 1994;114(4):559-565. 9. Gillman PK. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol 2007;151(6):737-748. 10. Tatsumi M, Groshan K, Blakely RD, Richelson E. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol 1997;340(2-3):249-258. 11. Martignoni M, Groothuis GMM, de Kanter R. Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and inductions. Expert Opin Drug Metab Toxicol 2006;2(6):875-894. 12. Bogaards JJP, Bertrand M, Jackson P, et al. Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. Xenobiotica 2000;30(12):1131-1152. 13. Turpeinene M, Ghiciuc C, Opritoui M, et al. Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica 2007;37(12):1367-1377. 14. Van Beusekom CD, Schipper L, Fin-Gremmels J. Cytochrome P450-mediated hepatic metabolism of new fluorescent substrates in cats and dogs. J Vet Pharmacol Ther 2010;33(6):519-527. 15. Haria M, Fitton A, McTavish D. Trazodone. A review of its pharmacology, therapeutic use in depression and therapeutic potential in other disorders. Drugs Aging 1994;4(4):331-55. 16. Gruen ME, Sherman BL. Use of trazodone as an adjunctive agent in the treatment of canine anxiety disorders: 56 cases (1995-1997). JAVMA 2008;233(12):1902-1907. 17. Gilbert-Gregory SE, Stull JW, Rice MR, Herron ME. Effects of trazodone on behavioral signs of stress in hospitalized dogs. JAVMA 2016;249(11):1281-1291. 18. Gertler R, Brown HC, Mitchell DH, Silvius EN. Dexmedetomidine: a novel sedative- analgesic agent. BUMC Proc 2001;14:13-21. 19. Varty GB, Cohen-Williams ME, Hunter JC. The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test. Behav Pharmacol 2003;14(1):87-95. Karen L. Overall Karen L. Overall, MA, VMD, PhD, DACVB, is a senior research scientist in the Biology Department at the University of Pennsylvania. She received her VMD degree from the University of Pennsylvania and her PhD from the University of Wisconsin-Madison. She did her residency training in veterinary behavioral medicine at the University of Pennsylvania. She has served on the faculties of both the veterinary and medical schools at the University of Pennsylvania and ran the Behavior Clinic at Penn Vet. Dr. Overall has been named the North American Veterinary Conference Small Animal Speaker of the Year. Her research focuses on neurobehavioral genetics of dogs, the development of normal and abnormal behaviors, and how behavior is assessed, especially as concerns working dogs. 104 FOCUS ON PHARMACOLOGY

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