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CLINICAL INSIGHTS JULY/AUGUST 2018 55 IMPORTANT SAFETY INFORMATION: F or oral use in dogs only. Not for human use. Keep out of reach of children. If accidentally ingested by humans, contact a physician immediately. The most commonly reported side effects were vomiting, loss of appetite, diarrhea, excessive salivation, agitation, tiredness, vocalization, confusion, increased water consumption, weight loss, weakness, fever, panting, and reversible changes in skin color (flushing or bright pink). Abnormal gait, seizures or tremors, as well as liver enzyme elevations, kidney failure, blood in urine and urine retention have been reported. In some cases death, including euthanasia has been reported. Sudden death was sometimes preceded by vocalization or collapse. Instances of dogs chewing through closed vials of PROIN and eating the vial contents have been reported, in some cases resulting in overdose. Keep the product in a secured storage area out of the reach of pets in order to prevent accidental ingestion or overdose, as dogs may willingly consume more than the recommended dosage of PROIN Chewable Tablets. Contact your veterinarian immediately if the dog ingests more tablets than prescribed or if other pets ingest PROIN Chewable Tablets. PROIN may cause elevated blood pressure and should be used with caution in dogs with pre-existing heart disease, high blood pressure, liver disease, kidney insufficiency, diabetes, glaucoma, and other conditions associated with high blood pressure. The safe use of PROIN in dogs used for breeding purposes, during pregnancy or in lactating bitches, has not been evaluated. Contact your veterinarian if you notice restlessness or irritability, loss of appetite, the incontinence persists or worsens, or any other unusual signs. See prescribing information for complete details regarding adverse events, warning and precautions or visit When house-trained dogs have accidents, smart owners look to veterinarians for answers. PROIN® (phenylpropanolamine hydrochloride) is the only FDA approved product for the management of urinary incontinence due to urethral sphincter hypotonus in dogs. Remember: P is for PROIN and PROIN is for Pee. Learn more at 800-874-9764 PROIN is a registered trademark of Pegasus Laboratories, Inc. ©2018 PRN Pharmacal. All rights reserved. PROIN-6-18-2 Urine trouble now! PROIN ® (phenylpropanolamine hydrochloride) CHEWABLE TABLETS PROIN® (Phenylpropanolamine hydrochloride) Chewable Tablets

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