Today's Veterinary Practice

TVP_JUL-AUG2018

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Wisdom Health, in collaboration with Genoscoper Laboratories, conducted an innovative study that shows genetic testing may predict if a dog is at risk for developing certain diseases. The study, published in PLOS Genetics, examined the DNA of more than 100,000 dogs, including 18,000 purebreds representing 330 breeds, types and varieties and 83,000 mixed breed dogs for the presence of 152 genetic disease mutations these breeds are most likely to develop. In addition, the study also revealed that in comparison to purebreds, fewer mixed breed dogs were affected by the most common disease-causing mutations. All of these findings were based on genetic testing technology that can be used at home. According to a company press release, "Knowing a dog's disease-related genetic make-up could enable owners, breeders, and veterinarians to make more informed decisions about a dog's health." The study revealed 2 key results: (1) Approximately 2 out of 100 mixed breed dogs are at risk of becoming affected and 40 out of 100 are carriers for at least one of the diseases; and (2) approximately 5 out of 100 purebred dogs are at risk of becoming affected and 28 out of 100 are carriers for at least 1 of the diseases. Commenting on the study, Cindy Cole, DVM, PhD, DACVCP, General Manager at Wisdom Health, "There has been a long-standing perception that mixed breed dogs are less disease-prone than purebred dogs. This DNA-testing-based evidence shows that while mixed breed dogs are in fact less likely than purebreds to develop the recessive disorders evaluated in the study, they may still be carriers. It's now clear that all dogs can benefit from genetic testing." ■ To view the study in its entirety, visit journals.plos.org ■ For more information on this study's impact, visit wisdompanel.com Groundbreaking Dog Genetics Study Shows Benefits of DNA Testing Clinically proven to improve GI signs in 21 days 1,2 and derm signs in 30 days 1 Crafted with highly hydrolyzed chicken protein and a single purified carbohydrate source Rich aroma, color and new kibble shape dogs can't resist ADVERSE REACTIONS TO FOOD Taking purity to the next level Prescription Diet ® z/d ® HillsVet.com ©2018 Hill's Pet Nutrition, Inc. ®/™ Trademarks owned by Hill's Pet Nutrition, Inc. 1 Loeffler A, Lloyd DH, Bond R, et al. Dietary trials with a commercial chicken hydrolysate diet in 63 pruritic dogs. Vet Rec. 2004;154:519-522. 2 Fritsch DA, Roudebush P, Allen TA, et al. Effect of two therapeutic foods in dogs with chronic nonseasonal pruritic dermatitis. Intern J Appl Res Vet Med. 2010;8(3)146-154.

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