37
JULY/AUGUST 2017
■
TVPJOURNAL.COM
PRACTICAL
PARASITOLOGY
TABLE 1 Overview of Flea Control Products
ACTIVE
INGREDIENT
TRADE NAMES WATER RESISTANCE SAFETY IN CATS
LIFE STAGES
AFFECTED
EFFICACY
AGAINST
TICKS?
SUITABLE
FOR FOOD
ALLERGIES?
TOPICAL
Imidacloprid
Advantage II
Advantage Multi
Advantix
Variable, may not be
sufficient in patients
that swim or are
bathed frequently
Yes, if not combined
with permethrin
(Advantix)
Adults, larvae
Only if
combined
with
permethrin
Yes
Fipronil
Frontline, many
others
Fair Yes
Adults only
(usually combined
with an IGR)
Yes Yes
Selamectin Revolution
Should be very good
beginning 2 h
after bathing
Yes Adults, larvae Yes Yes
Indoxacarb
Activyl
Activyl Tick Plus
Moderate
Yes, if not combined
with a pyrethroid
(Activyl Tick Plus)
Adults, larvae
Only if
combined
with
permethrin
Yes
Permethrin Many Probably moderate No Adults only Yes Yes
Flumethrin Seresto
Continuously replenished
from collar
Yes Adults only Yes Yes
Dinotefuran
Vectra
Vectra 3D
Moderate
Yes, if not combined
with a pyrethroid
(Vectra 3D)
Adults only
(usually combined
with an IGR)
Only if
combined
with
permethrin
Yes
Spinetoram Cheristin Unknown Yes (cats only) Adults, eggs No Yes
Fluralaner Bravecto topical
Good, beginning 3 d
after application
Yes Adults Yes Yes
ORAL
Spinosad
Comfortis
Trifexis
Waterproof Yes Adults, eggs No
Contains
pork
Nitenpyram Capstar Waterproof Yes Adults only No Yes
Afoxolaner NexGard Waterproof
Not labeled for cats, but
okay in households with
treated dogs
Adults only Yes
Contains
soy
Fluralaner Bravecto Waterproof
Not labeled for cats, but
okay in households with
treated dogs
Adults only
Fluralaner may
also have some
effects on larvae
Yes
Contains
pork
Sarolaner Simparica Waterproof
Not labeled for cats, but
okay in households with
treated dogs
Adults only Yes
Contains
pork
INSECT GROWTH REGULATORS
Lufenuron Sentinel Waterproof Yes Larvae, eggs No
Contains
pork
Methoprene Many Probably poor Yes Larvae, eggs No Yes
Pyriproxyfen Many Probably poor Yes Larvae, eggs No Yes
Manufacturer information for products not mentioned in text: Revolution— zoetis.com; Cheristin—elanco.us. IGR, insect growth regulator.